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Thursday, May 24, 2007

Deplin = Depression Remission!

About a month ago, I awoke to a pretty day. The weather had been nice for a week or so, and I had been cheered by it. On this day, though, I did not just smile at the memory of enjoying such beautiful days. I was softly filled with happiness. The emotion was elating in itself, and wonderful combined with the beauty of my backyard.

I was happy.

I easily recognized the feeling, even though I had not experienced it once in the last three to four years. My depression has been varying degrees of controlled, or not, throughout my adulthood. I have not, however, had any remission. I have been a difficult patient to manage. My psychiatrist and I have tried every possible combination of treatments available. Numerous medications left me worse-off, sometimes permanently, than I had been. Others could not be tried because they were contra-indicated by other conditions.

Two or three days before I awakened to happiness, my doctor had given me a thirty-day sample package of Deplin. It was a brand new product, and I was going to be about the fourth of her patients to try it. The first Guinea pig was a lady who was an even more difficult case than I. After years of treatment, including fairly consistent close supervision, she was much better, required less supervision, and appeared to be rapidly headed toward being a fully functioning outpatient. Despite my run of bad luck with trying the the latest and greatest side-effects on the market, I was eager to try the Deplin.

Deplin is not a drug, although it requires a prescription. It is called a "medical food." I have never studied chemistry, but could sort of follow the explanation about it being some mirror image of a rotated variant of an altered molecule of a specific type of folate, or something like that. I guess, in even less sophisticated terms, I would call it a designer vitamin. You will not find this at your local health food store.

Folate, especially this patented and highly potent version, is essential to the production of dopamine, serotonin, and norepinephrine: the three neuro-transmitters (brain-soup ingredients) most critical to the disease-process and treatment of depression. Taking Deplin gives the brain a supply of an essential ingredient needed to produce adequate amounts of these neuro-transmitters.

A simple across-the-board increase of the supply of those particular three neuro-transmitters would not conscientiously address the complexities of tampering with the brain-soup. For example, Deplin would not create the proper proportions of the soup ingredients for each patient, nor address the matter of how the levels of these chemicals affect the levels of other important neuro-transmitters. Taking Deplin alone could actually cause or exacerbate a chemical imbalance in the brain. The soup might have a stronger "flavor," but it might be more potently "foul." Deplin is, therefore, approved for use only as an "adjunct therapy." The proportions of the neurotransmitters must be managed with other appropriate medications prescribed for mood disorders.

I hope my explanation has been accurate and useful. I am excited, not just for myself, but also for the millions of fellow sufferers in our nation. Since starting the Deplin, I have heard of nothing but additional cases of "miraculous," swift reductions and remissions of depression upon starting Deplin.

If Deplin is so strongly effective across-the-board, I believe its success will actually be seen in the economy. Depression is the most common mental illness. Depression can remove people like me from the workforce entirely, severely impair the efficiency and job performance of the afflicted, cause absenteeism and tardiness among such employees, and the presence of depressed workers can even harm morale among healthy co-workers and subordinates. If there is a "cure" for depression, a huge economic drain on our GDP will be replaced by a surge in per capita production. Nice!

Now we come to an ironic issue I face. My date of disability was, as SSA readily admitted, set arbitrarily. I have until April of next year to request a reconsideration. If I can show a significantly earlier date of disability (I can), I will receive a small additional lump-sum payment, and a substantial increase in my monthly payments. I have put off pursuing this for three years; I was too depressed to do anything about it, even though I knew how important a matter it is. It has only been a few weeks since a started taking my daily dose of Deplin, but so far I have improved to the point that preparing my appeal seems like a straight-forward, easily manageable matter.

In fact, I might simultaneously begin the process of applying for a Return-to-Work trial period. Once granted, you may work, with your disability check reduced (often to nothing, but you keep Medicare) by your earnings. You have up to thirty-six months to call-off the experiment, stop working, and return to receiving your ordinary monthly checks.

If you are able to continue working beyond thirty-six months, you have the option to continue on Medicare. The premiums are subsidized during some phase of the Return-to-Work program; after that, you must pay in full. Many who successfully re-enter the job-market find other, more affordable medical coverage, despite a history of having been on Social Security Disability. Personally, I would need to continue my Medicare coverage. It is generous with mental health services and prescriptions, which comprise the lion's share of my high annual out-of-pocket medical expenditures. Typical private insurance policies have sharply curtailed mental health coverage, offering little per incident and a tiny lifetime allowance. In fact, my constellation of diagnoses would probably preclude my even obtaining a useful private insurance policy.

Well, that is the topic which seemed to me worth the first headline. I hope this might help someone else. Please spread the hopeful word about Deplin!
Comments:
AMAZING news!! I'm so happy for you!
I need to send Wandering Coyote over here. She's on disability for Borderline Personality Disorder and constantly struggles with depression. She's tried just about every med out there, to no avail.
 
Hi Sagepaper,

Tshsmom sent me here. As she mentions, I suffer from BPD but also very severe depressions, sometimes requiring months in hospital and even a series of ECT treatments. I've been hospitalized 4 times in the last year, and have also been diagnosed with dysthymia. I'm in a therapy group designed for BPD specifically, but still take 4 drugs for the depression. I am considered "disabled" by both my provincial and federal governments and receive a small income and have all my medical expences paid for. So glad to live in Canada! Anyway, I found this a very interesting post, but cannot seem to find out if Deplin is available in Canada, so I'm going to talk to my shrink about this when I see him in a week. I'm glad it's being touted as an adjunct therapy that boosts the effects of medications, rather than a magical pill to take instead of medications.

I'm so glad to hear you are feeling so much better. That's always good news and a victory to celebrate!

I'll let you know what I find out about Deplin in Canada next week.

Take good care,

WC.
 
Wandering Coyote,
You and I are in very similar circumstances. My three disability diagnoses are Depression, Tourette's, and BPD. I'm at the place where I don't think BPD is accurate. Finding a support group might be enlightening. How is yours?
 
Sage: BPD is a tough one. Sometimes I can totally see it in myself and agree with the diagnosis, and sometimes I think it's completely wrong. I've read four different books on BPD and couldn't relate with any of them, except one called LOST IN THE MIRROR, which I highly recommend. The group I'm in isn't a support group per se, it's Dialectic Behavioural Therapy (DBT) which is a skills-based group developed by a woman in the States specifically for BPD. There is a lot of sharing that goes on in the group, but it's also very skills-based. If you can get into one, I'd recommend it.
 
Dysthymic Disorder is characterized by chronic depression, but with less severity than a major depression. The essential symptom for dysthymic disorder is an almost daily depressed mood for at least two years, but without the necessary criteria for a major depression. Low energy, sleep or appetite disturbances and low self-esteem are usually part of the clinical picture as well. http://www.xanax-effects.com/
 
I'm 47 and have had serious, treatment resistant depression since my early 20s. Antidepressants have offered me some relief, though it has been far from complete. Although I have remained consistently on antidepressants since Prozac was released, my depression has been bad enough to cause me to try to commit suicide about a year ago.
I've been muddling along on Pristiq (the new, patent extending Effexor) and Welbutrin. Recently my doc had me on Ritalin as well, to give me the energy just to make it through the day.
She put me on Deplin a week ago and its effect on me was felt the next day. After a night of extremely colorful dreams, I woke up feeling great. I took my medicine as usual and it was suddenly as if my brain could feel all the antidepressants for the first time. I spent a trippy weekend, got in touch with my doc on Monday, immediately discontinued Ritalin. I'm still feeling great, full of energy, and still feeling over medicated. I suspect the next step might be to reduce, if not discontinue, the Pristiq and Welbutrin.
This is the first time I've ever actually thought I may have found a "cure" for lifelong depression. It's only been about a week now, but I remain cautiously optimistic.
 
Is the deplin still working?
 
Hi,

I'm really glad I was able to read about your experiences with Deplin. Thank you for sharing. I was wondering about something you wrote though. Where did you find the information about it being bad to take Deplin alone, without any other medication? I'd greatly appreciate reading your sources as I am considering going on Deplin without any other meds. Thanks!
 
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